Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A β1- and β2-
adrenergic receptor agonist .
Etymologies
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Examples
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Protecting the gut and the liver in the critically ill: effects of dopexamine.
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Systemic and regional oxygen uptake and lactate flux in endotoxic dogs resuscitated with dextran and dopexamine or dextran alone.
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Although potentially promising, dopexamine cannot be considered part of the standard therapeutic regimen for the treatment of hemodynamic insufficiency in patients with sepsis on the basis of current evidence.
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These159,165,166 and other studies seem to suggest a potential benefit from dopexamine in patients with sepsis and septic shock.
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With dopexamine hepatic blood flow was increased, and gastric intramucosal pH also improved significantly; these effects were sustained after discontinuation of dopexamine, suggesting that dopexamine may improve splanchnic oxygenation independent of its effects on systemic hemodynamics. 166 These studies are small, and the effects of dopexamine on gastric intramucosal pH have not been consistently reproducible.
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These strategies include dopexamine, inhibitors NO2, and use of extracorporeal circuits to remove toxic mediators.
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Colardyn et al. 165 evaluated the use of dopexamine in ten patients with septic shock and observed a short-term increase in cardiac index and HR and a dose-dependent decrease in systemic vascular resistance.
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Palsson J, Ricksten SE, Houltz E, Lundin S. Effects of dopamine, dopexamine and dobutamine on renal excretory function during experimental sepsis in conscious rats.
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Over the long term, tolerance may have developed, as these effects gradually diminished. 165 Hannemann et al. 159 evaluated the effects of a 30-min infusion of dopexamine (2 µg / kg / min) in 29 postoperative patients with septic shock and noted an increase in cardiac index and oxygen delivery, and a slight (4\%) but statistically significant increase in oxygen consumption; the oxygen extraction ratio decreased by approximately 8\%.
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Lund et. al. 160 documented improved tissue oxygenation in gut, liver, and skeletal muscle with dopexamine in septic rabbits in a dose-dependent manner. 161 Similarly, Cain and Curtis161,162 observed an increase in systemic oxygen delivery and oxygen consumption with dopexamine and suggested improved gut mucosal perfusion in endotoxemic dogs.
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