downmodulation love


from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun modulation to a lower level


Sorry, no etymologies found.


Help support Wordnik (and make this page ad-free) by adopting the word downmodulation.


  • We demonstrated a significant downmodulation of the main pathways implicated in bone and cartilage destruction in RA: the MMP / TIMP system and the OPG / RANKL system.

    Recently Uploaded Slideshows 2009

  • • Therapy with TNF antagonists such as etanercept and infliximab is highly active in patients with RA through downmodulation of both synovial inflammation and cartilage and bone destruction.

    Recently Uploaded Slideshows 2009

  • Altogether, these results show that zinc counteracted hypoxia-induced HIPK2 downmodulation, recovered the HIPK2 recruitment onto chromatin and led to repression of the HIF-1 pathway.

    PLoS ONE Alerts: New Articles Lavinia Nardinocchi et al. 2009

  • Notably, zinc supplementation to hypoxia-treated cells counteracted the inhibition of HIPK2 allowing its nuclear accumulation that correlated with HIF-1α downmodulation and repression of the HIF-1 pathway and with restoration of p53Ser46 apoptotic transcriptional activity in response to drug.

    PLoS ONE Alerts: New Articles Lavinia Nardinocchi et al. 2009


Log in or sign up to get involved in the conversation. It's quick and easy.