Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- abbreviation
double-stranded RNA
Etymologies
Sorry, no etymologies found.
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Examples
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As discussed in my lecture, dsRNA is not the only trigger for this silencing mechanism.
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We now know that dsRNA is both a trigger and intermediate in RNAi.
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It has been proposed that in transposon-containing regions of the genome both DNA strands are transcribed, dsRNA is formed, and the RNAi process eliminates these undesirable products.
Advanced Information: The 2006 Nobel Prize in Physiology or Medicine 2006
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They established that long dsRNA is cleaved to small RNA (about 25 nucleotides long), and that antisense RNA triggers degradation of mRNA via base-pairing to mRNA.
Advanced Information: The 2006 Nobel Prize in Physiology or Medicine 2006
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It could be shown that dsRNA is processed to 21-23 nucleotide long dsRNA fragments31, which was in good agreement with the data for PTGS in plants29.
Advanced Information: The 2006 Nobel Prize in Physiology or Medicine 2006
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They synthesize dsRNA with a sequence that matches the intended target; this dsRNA is often called siRNA (small interfering RNA).
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This indicated that the dsRNA was amplified and/or acted catalytically rather than stoichiometrically.
Advanced Information: The 2006 Nobel Prize in Physiology or Medicine 2006
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In the lab, writes its inventor, Todd Rider of MIT's Lincoln Laboratory, "we have demonstrated that Dracos are effective against viruses with DNA, dsRNA, positive-sense ssRNA, and negative-sense ssRNA genomes; enveloped and nonenveloped viruses; viruses that replicate in the cytoplasm and viruses that replicate in the nucleus; human, bat and rodent viruses; and viruses that use a variety of cellular receptors."
Modifying Mother Nature to Kill Nasty Viruses Matt Ridley 2011
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However, importantly, dsRNA turned out to be a highly conserved trigger that rapidly led to the application of RNAi in diverse species including humans.
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It was Andy's suggestion that dsRNA contaminating our preparations could be the actual trigger molecule underlying RNAi.
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