Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
glycoprotein located on the surface of cells
Etymologies
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Examples
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The drugs act on an enzyme linked to production of these proteins, soluble FLt-1 and soluble endoglin.
BBC News - Home 2011
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The other factor, soluble endoglin, is a co-receptor for TGF-β
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The TGF-β pathway controls growth and Gingery proposes that soluble endoglin inhibits cell growth by reducing the signaling of this pathway.
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Gingery studies two factors released during preeclampsia: sFlt-1 and soluble endoglin. sFlt-1 is a soluble version of a protein called VEGF (vascular endothelial growth factor), which regulates the growth of cells.
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Mutations in endoglin and activin-like kinase receptor 1 (ALK1) cause hereditary hemorrhagic telangiectasia, whereas bone morphogenetic protein type II receptor (BMPR-II) mutations underlie familial pulmonary arterial hypertension.
Journal of Biological Chemistry current issue P. D. Upton 2009
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However, small interfering RNA and inhibitor studies showed no involvement of ALK5 or endoglin.
Journal of Biological Chemistry current issue P. D. Upton 2009
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To do that, they injected mice with a virus that produces large quantities of soluble endoglin, a protein that would circulate, and then bind to and inhibit TGF-beta.
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Genetic linkage studies identified two genes primarily related to HHT: endoglin (ENG) on chromosome 9q33-34 and activin receptor-like kinase1 (ACVRL1) on chromosome 12q13.
BioMed Central - Latest articles Haneen Sadick 2009
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To do that, they injected mice with a virus that produces large quantities of soluble endoglin, a protein that would circulate, and then bind to and inhibit TGF-beta.
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Ets related gene (ERG) has recently been shown to participate in the transcriptional regulation of a number of endothelial specific genes including VE-cadherin (CD144), endoglin, and von Willebrand's Factor (vWF).
BioMed Central - Latest articles Vesna Nikolova-Krstevski 2009
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