Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
vasoconstricting oligopeptide that plays a key role invascular homeostasis .
Etymologies
Sorry, no etymologies found.
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Examples
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The three drugs block a chemical called endothelin that causes blood vessels to constrict.
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It is already proven that Walnuts have the ability to control the levels of endothelin, which is the primary cause for the inflammation of blood vessels.
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In their experiments on mice with scarring diseases, the researchers also found elevated levels of a protein called endothelin-1.
India eNews 2008
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Investigators also found elevated levels of a protein called endothelin-1.
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It is these polyphenols that are responsible for acting on blood vessels to suppress endothelin production and thus help prevent heart disease.
Drinking to Good Health Will Lyons 2010
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And another study found that postmenopausal women with elevated testosterone had increases in markers of inflammation and endothelial dysfunction, C-reactive protein (CRP) and endothelin, that have been associated with increased risk of atherosclerosis.
Doug Bremner: Wow! A Drug That Will Let Me Have Sex Once More a Month? Sign Me Up! 2008
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Macitentan is a highly potent, tissue-targeting endothelin receptor antagonist discovered in an in-house research program.
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Actelion's first drug Tracleer®, an orally available dual endothelin receptor antagonist, has been approved as a therapy for pulmonary arterial hypertension.
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In contrast to the tolerability profile of other endothelin receptor antagonists in previous clinical studies, there were no relevant findings of headache, hypotension, nasopharyngitis, rhinitis and hot flush.
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Through complete blockade of tissular endothelin, macitentan is expected to protect tissue from the damaging effect of elevated endothelin, specifically in the cardiovascular system.
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