Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry A vasoconstricting oligopeptide that plays a key role in vascular homeostasis.

Etymologies

Sorry, no etymologies found.

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Examples

  • The three drugs block a chemical called endothelin that causes blood vessels to constrict.

    BusinessWeek.com -- Top News 2012

  • It is already proven that Walnuts have the ability to control the levels of endothelin, which is the primary cause for the inflammation of blood vessels.

    ReadABlog.com New Blogs and RSS Feeds 2010

  • In their experiments on mice with scarring diseases, the researchers also found elevated levels of a protein called endothelin-1.

    India eNews 2008

  • Investigators also found elevated levels of a protein called endothelin-1.

    Health News from Medical News Today 2008

  • It is these polyphenols that are responsible for acting on blood vessels to suppress endothelin production and thus help prevent heart disease.

    Drinking to Good Health Will Lyons 2010

  • And another study found that postmenopausal women with elevated testosterone had increases in markers of inflammation and endothelial dysfunction, C-reactive protein (CRP) and endothelin, that have been associated with increased risk of atherosclerosis.

    Doug Bremner: Wow! A Drug That Will Let Me Have Sex Once More a Month? Sign Me Up! 2008

  • Macitentan is a highly potent, tissue-targeting endothelin receptor antagonist discovered in an in-house research program.

    Reuters: Press Release 2011

  • Actelion's first drug Tracleer®, an orally available dual endothelin receptor antagonist, has been approved as a therapy for pulmonary arterial hypertension.

    Reuters: Press Release 2011

  • In contrast to the tolerability profile of other endothelin receptor antagonists in previous clinical studies, there were no relevant findings of headache, hypotension, nasopharyngitis, rhinitis and hot flush.

    Reuters: Press Release 2011

  • Through complete blockade of tissular endothelin, macitentan is expected to protect tissue from the damaging effect of elevated endothelin, specifically in the cardiovascular system.

    Reuters: Press Release 2011

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