Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry The
univalent radical derived fromfarnesol
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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C1-atom of the farnesyl moiety is 3.8 Å (red dashed line).
PLoS ONE Alerts: New Articles Michael L. Nickerson et al. 2010
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Green spheres represent magnesium cations in the active site with a docked farnesyl-diphosphate (red stick representation).
PLoS ONE Alerts: New Articles Michael L. Nickerson et al. 2010
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The quinone moiety and farnesyl chain are recognized by P64, F107, and other indicated residues via hydrophobic interactions. doi: 10.1371/journal. pone.0010760.g006
PLoS ONE Alerts: New Articles Michael L. Nickerson et al. 2010
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(F) Active site of UBIAD1 with a menaquinone-farnesyl derivative that optimally docks to the protein.
PLoS ONE Alerts: New Articles Michael L. Nickerson et al. 2010
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Mao J, Mukherjee S, Zhang Y, Cao R, Sanders JM, et al. (2006) Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
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In parallel, recently crystallographic and computational investigation revealed that the presence of phenyl ring in the side chain permitted non N-BPs to interact with farnesyl enzyme
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David E, Sun SY, Waller EK, Chen J, Khuri FR, et al. (2005) The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT.
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Also, the addition of phenyl function in the side chain of BPs rendered the catalytic pocket of geranyl and / or farnesyl synthase enzymes of the mevalonate pathway more accessible
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N-BPs, such as zoledronate, acted on the mevalonate pathway inhibiting the farnesyl diphosphate synthase (FPP) thereby depleting the cells of the farnesyl (FPP) or geranylgeranyl (GGPP) diphosphate isoprenoids
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The C-terminal CaaX box of RhoH is mainly a target for farnesyl-transferase but can also be modified by geranylgeranyl-transferase.
BioMed Central - Latest articles Florian Fueller and Katharina F Kubatzky 2008
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