fmk

IL-3 withdrawal causes receptor-interacting protein (RIP) 1 cleavage into C-terminal fragments of 30 and 25 kDa, and only cleavage leading to the former was prevented by zVAD-fmk. siRNA experiments demonstrated that generation of the 25-kDa fragment was due to a Bcl-2-modulated release of the mitochondrial serine protease high temperature requirement protein A2 (HtrA2)/Omi.

Naturejobs - All Jobs Lieselotte Vande Walle 2010

Interestingly, knockdown of HtrA2/Omi afforded protection against IL-3 withdrawal-induced death in the presence of zVAD-fmk, demonstrating a role for HtrA2/Omi in caspase-independent cell death during growth factor withdrawal by cleaving RIP1.

Naturejobs - All Jobs Lieselotte Vande Walle 2010

Interestingly, knockdown of HtrA2/Omi afforded protection against IL-3 withdrawal-induced death in the presence of zVAD-fmk, demonstrating a role for HtrA2/Omi in caspase-independent cell death during growth factor withdrawal by cleaving RIP1.

Naturejobs - All Jobs Lieselotte Vande Walle 2010

Interestingly, knockdown of HtrA2/Omi afforded protection against IL-3 withdrawal-induced death in the presence of zVAD-fmk, demonstrating a role for HtrA2/Omi in caspase-independent cell death during growth factor withdrawal by cleaving RIP1.

Naturejobs - All Jobs Lieselotte Vande Walle 2010

IL-3 withdrawal causes receptor-interacting protein (RIP) 1 cleavage into C-terminal fragments of 30 and 25 kDa, and only cleavage leading to the former was prevented by zVAD-fmk. siRNA experiments demonstrated that generation of the 25-kDa fragment was due to a Bcl-2-modulated release of the mitochondrial serine protease high temperature requirement protein A2 (HtrA2)/Omi.

Naturejobs - All Jobs Lieselotte Vande Walle 2010

IL-3 withdrawal causes receptor-interacting protein (RIP) 1 cleavage into C-terminal fragments of 30 and 25 kDa, and only cleavage leading to the former was prevented by zVAD-fmk. siRNA experiments demonstrated that generation of the 25-kDa fragment was due to a Bcl-2-modulated release of the mitochondrial serine protease high temperature requirement protein A2 (HtrA2)/Omi.

Naturejobs - All Jobs Lieselotte Vande Walle 2010

Activity in this assay is inhibited by the pan-caspase inhibitor zVAD-fmk

PLoS ONE Alerts: New Articles 2009

So into this fink; in this lie hid in the evil hour; zwi the temptations will pafs away, and the tempmis ftrength be broken, and the arm of the Lord (which brake him) revealed; and then ye ihall fee, that he railed but a fea of trouble in your fouls, to fmk himfdf by; and the Lord will throw the horfe and his rider

Letters of Isaac Penington, Written to His Relations and Friends, Now First Published from ... 1796

On a late divifion of the Privy Council, they feized an early opportunity to fpeak, as a Body, (nay, ufed thefe words) and even by anticipation — to call the caufe before their own tribunal — tbe other tribunals were of courfe to fmk in the pub - lic efiimation.

A letter on the nature and tendency of the Whig Club and of Irish party 1791

And all this fair-ere6led fky Muft fmk with earth and fea, and melt away in fire.

The works of the English poets; with prefaces, biographical and critical 1790