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Examples
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GSK purchased the test drug, fondaparinux, from the French company Sanofi-Synthelabo now Sanofi-Aventis, in 2004 when the trial had already started in India.
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One way to avoid the possibility of giving a patient with heparin induced thrombocytopenia more heparin is to use fondaparinux to treat DVT and PE since it does not cross react with the HIT antibodies.
Should we consider HIT (heparin induced thrombocytopenia) in cases of DVT and PE? james gaulte 2007
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One problem with this is that fondaparinux is not approved in the U.S.for treatment of HIT only argatroban and lepirudin are.
Archive 2007-01-01 james gaulte 2007
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One problem with this is that fondaparinux is not approved in the U.S.for treatment of HIT only argatroban and lepirudin are.
Should we consider HIT (heparin induced thrombocytopenia) in cases of DVT and PE? james gaulte 2007
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One way to avoid the possibility of giving a patient with heparin induced thrombocytopenia more heparin is to use fondaparinux to treat DVT and PE since it does not cross react with the HIT antibodies.
Archive 2007-01-01 james gaulte 2007
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Additionally, in July, the US Food and Drug Administration FDA approved fondaparinux sodium injection, the company's bioequivalent generic version of Arixtra.
unknown title 2011
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Previous study results suggested the use of unfractionated heparin as supplemental therapy at the time of percutaneous coronary intervention (PCI; procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries) for patients with non-ST segment elevation (a certain pattern on an electrocardiogram) acute coronary syndromes (such as heart attack or unstable angina) who were treated with fondaparinux and undergoing PCI.
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The authors note that the major finding of this study is that low fixed-dose heparin is not superior to standard ACT-guided heparin dosing (after the use of fondaparinux) in terms of preventing peri-PCI major bleeding or major vascular access site complications.
Science Blog 2010
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"These findings support using the currently recommended standard ACT-guided dose of unfractionated heparin when performing PCI in patients with non-ST segment elevation acute coronary syndromes who are treated with fondaparinux."
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The randomized trial included 179 hospitals in 18 countries and involved 2,026 patients undergoing PCI within 72 hours, who were from a group of 3,235 high-risk patients with non-ST segment elevation acute coronary syndromes initially treated with fondaparinux, enrolled from February 2009 to March 2010.
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