gain-of-function

Loss-of-function and gain-of-function experiments revealed that these regulatory T cells influenced the inflammatory state of adipose tissue, insulin resistance, and glucose uptake.

Dr. Sharma’s Obesity Notes » Blog Archive » Will Immunotherapy Provide a New Treatment for Obesity? 2009

The anti-CML therapy, imatinib (Glivec or Gleevec, depending on which country you are in) acts by inhibiting the BCR-ABL gene product (a gain-of-function mutant which persistently activates growth pathways).

That's another fine mess you've made Jonathan! - The Panda's Thumb 2005

These results support the prevailing toxic-RNA gain-of-function disease model in which the repeat expansions do not reduce ZNF9 activity but rather interfere with other critical processes.

PLoS ONE Alerts: New Articles Morgan A. Sammons et al. 2010

The mutation detected in the clinical isolate VPCI591 therefore behaves like a gain-of-function mutation.

BioMed Central - Latest articles 2010

First, a gain-of-function disease model hypothesizes that the repeat expansions in the transcribed RNA do not directly affect ZNF9 function.

PLoS ONE Alerts: New Articles Morgan A. Sammons et al. 2010

These data support the notion that the ZNF9 protein may play a role in DM2 and that the RNA-mediated dominant gain-of-function model for myotonic dystrophy is not the only pathomechanism for the disease. in vivo biochemical function for ZNF9 has hindered the ability to clearly define the role that ZNF9 plays in DM2.

PLoS ONE Alerts: New Articles Morgan A. Sammons et al. 2010

"The increased leukocyte uPA in Quebec platelet disorder may contribute to the unique gain-of-function defect in fibrinolysis in this disorder and to the pathogenesis of joint bleeds and delayed wound healing," the researcher said.

MedPageToday.com - medical news plus CME for physicians 2010

However, ranolazine's effects on gain-of-function mutations of Nav1. 7 and on DRG neuron excitability have not been investigated.

BioMed Central - Latest articles Mark Estacion 2010

Quebec platelet disorder is an autosomal dominant bleeding condition associated with a gain-of-function defect in fibrinolysis resulting from a 78 kb tandem duplication on chromosome 10q24 that includes

MedPageToday.com - medical news plus CME for physicians 2010

A direct role of sodium channels in pain has recently been confirmed by establishing a monogenic link between SCN9A, the gene which encodes sodium channel Nav1. 7, and pain disorders in humans, with gain-of-function mutations causing severe pain syndromes, and loss-of-function mutations causing congenital indifference to pain.

BioMed Central - Latest articles Mark Estacion 2010