Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun
galactocerebroside
Etymologies
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Examples
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Chen A, Li X, Chen Z, Zhang W, et al. (2008) Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, a-galactosylceramide.
PLoS ONE Alerts: New Articles Sandhya Vasan et al. 2010
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The pathological changes observed in GLD, including the presence of globoid cells (macrophages containing undigested galactosylceramide) in white matter, loss of oligodendrocytes and decreased myelin, appear to result from the toxic nature of psychosine and accumulation of galactosylceramide that cannot be degraded due to the GALC deficiency.
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GALC is responsible for the lysosomal hydrolysis of certain galactolipids located mainly in myelin, galactosylceramide and psychosine (galactosylsphingosine).
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KRN7000, a synthetic derivative of alpha-galactosylceramide, is a small molecule that potently activates natural killer T (NKT) cells.
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KRN7000, a synthetic derivative of alpha-galactosylceramide, is a small molecule that potently activates natural killer T (NKT) cells.
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We also investigated the function of another population of self-reactive T cells that develop in the thymus, natural killer T (NKT) cells. 90 min after injection of the NKT cell-specific agonist alpha-galactosylceramide (αGalCer), elevated concentrations of IL-4 and IFNγ were measured in the serum of king mice, indicating that the mutation did not impair pan-T cell function (
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