gastrins

For all practical purposes this antiserum does not crossreact with CCK-8 or the gastrins, big or little, in spite of their sharing a common COOH-terminal pentpeptide.

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977

Both gastrins were found in extracts of a ZE tumor as well as in extracts of the antrum and proximal small bowel (22).

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977

It is evident that the observed heterogeneity introduces complications into bioassay, as well as into immunoassay, since biologic activity as defined by the traditional dose-response method is certainly different from that defined by plasma concentration-response data in the case of the gastrins or any other groups of biologically active related peptides with different turnover times.

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977