Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine A particular
benzoquinone ansamycin antibiotic
Etymologies
Sorry, no etymologies found.
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Examples
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Many pharmacological inhibitors of Hsp90 such as geldanamycin and 17-AAG target the amino-terminal ATP binding pocket of Hsp90, thereby inhibiting its chaperone function
PLoS Biology: New Articles Daniel W. Neef et al. 2010
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(A) Yeast cells were treated with either 10 µM HSF1A, 10 µM geldanamycin, or 10 µM radicicol and growth was assessed as in
PLoS Biology: New Articles Daniel W. Neef et al. 2010
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To test this hypothesis, the efficacy of the potent Hsp90 inhibitors geldanamycin and radicicol, in promoting human HSF1-dependent yeast growth was evaluated.
PLoS Biology: New Articles Daniel W. Neef et al. 2010
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Similar results have been described for the Hsp90 inhibitor geldanamycin, which was able to rescue cell viability in a
PLoS Biology: New Articles Daniel W. Neef et al. 2010
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Given that geldanamycin and radicicol cannot promote human HSF1-dependent yeast growth and that HSF1A does not interact with Hsp90, together these data strongly suggest that HSF1A is not acting as an Hsp90 inhibitor in activating HSF1 in yeast or mammalian cells.
PLoS Biology: New Articles Daniel W. Neef et al. 2010
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Examples of each class include pertuzumab and trastuzumab (which block dimerization and suppress signaling by binding to extracellular domains II and IV, respectively); the HER2/neu TK-inhibitor lapatinib; and Hsp90 inhibitors including geldanamycin derivatives,
PLoS ONE Alerts: New Articles Jason P. Holland et al. 2010
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L (2006) Chaperoning oncogenes: Hsp90 as a target of geldanamycin.
PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010
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M (2005) Mechanisms of suppression of {alpha} - synuclein neurotoxicity by geldanamycin in Drosophila.
PLoS Biology: New Articles Daniel W. Neef et al. 2010
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Examples of each class include pertuzumab and trastuzumab (which block dimerization and suppress signaling by binding to extracellular domains II and IV, respectively); the HER2/neu TK-inhibitor lapatinib; and Hsp90 inhibitors including geldanamycin derivatives,
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The inability of well-established inhibitors of both mammalian and yeast Hsp90, geldanamycin and radicicol, to promote HSF1-dependent yeast growth suggests that HSF1A is promoting HSF1 activation in yeast independent of Hsp90 inhibition.
PLoS Biology: New Articles Daniel W. Neef et al. 2010
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