Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun One of the three
enzymes in theprenyltransferase group.
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
Support
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Examples
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Farnesyl transferase; geranylgeranyltransferase I (PGGT1B; GGTase I)
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Farnesyl transferase; geranylgeranyltransferase I (PGGT1B; GGTase I)
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Farnesyl transferase; geranylgeranyltransferase I (PGGT1B; GGTase I)
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Lu J, Chan L, Fiji HD, Dahl R, Kwon O, et al. (2009) In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I.
PLoS ONE Alerts: New Articles Guillaume Sarrabayrouse et al. 2010
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Mukai M, Tatsuta M, Matsumoto Y, Nakamura H, et al. (2003) Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.
PLoS ONE Alerts: New Articles Guillaume Sarrabayrouse et al. 2010
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GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that induces apoptosis by downregulating several pivotal oncogenic and tumor survival pathways.
unknown title 2009
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March 4 / PRNewswire / -- Tigris Pharmaceuticals, Inc., a privately held drug development company, today announced that its Investigational New Drug (IND) application for the Company's geranylgeranyltransferase inhibitor (GGTI-2418) has been accepted by the U.S.
unknown title 2009
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This is the first geranylgeranyltransferase inhibitor to move to clinical phase studies. "
unknown title 2009
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