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- noun biochemistry Either of a pair of related
thiol-dependent enzymes: glyoxalase І, which catalysesthe isomerisationof the spontaneously formed hemithioacetal adductbetween GSH and 2-oxoaldehydes (such as methylglyoxal) into S-2-hydroxyacylglutathione; and glyoxalase ІІ, which hydrolysesthese thiolesters.
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It was perhaps for this reason that the next enzyme, of the sequence, glyoxalase
The detoxification of reactive ketoaldehydes such as methylglyoxal (MG) by glyoxalase I and II protects cells from formation of advanced glycation end products (AGEs).
PLoS ONE Alerts: New Articles Arunava Dasgupta et al. 2010
Landgraf R, Kessler MS, Bunck M, Murgatroyd C, Spengler D, et al. (2007) Candidate genes of anxiety-related behavior in HAB / LAB rats and mice: focus on vasopressin and glyoxalase-I.
Kessler MS, Milfay D, Birg IN, Bunck M, et al. (2005) Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.