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  • noun biochemistry Any of a series of serine proteases that are released by cytoplasmic granules within natural killer cells.


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  • We characterized for the first time the expression and function of granzyme G during early stage embryogenesis.

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  • However, the pattern of granzyme G expression and its function in early mouse embryos are entirely unknown.

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  • One of these clones, which is expressed in 2-cell stage embryos at 48 hr post-hCG injection, shows a perfect sequence homology to the gene encoding the granzyme G protein.

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  • Fig. 1, CD62L, granzyme-K and CD27 were highly expressed in

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  • The granzyme family members are serine proteases that are present in the secretory granules of cytolytic T lymphocytes.

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  • Upon the introduction of an antisense morpholino (2 mM) against granzyme G to knock-down endogenous gene function, all embryos were arrested at the 2 - to 4-cell stages of egg cleavage, and the de novo synthesis of zygotic RNAs was decreased.

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  • Our data suggest that granzyme G is an important factor in early mouse embryonic development and may play a novel role in the elimination of maternal proteins and the triggering of zygotic gene expression during the maternal-zygotic transition.

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  • These included Pen5, CD8α, perforin and granzyme-B, which were expressed mainly on CD56 dim cells, independently of NKG2A expression.

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  • Various other stimuli (granzyme B, chemotherapeutics, irradiation and growth factor depletion) induce release of cytocrome c from mitochondria that together with Apaf-1 will induce activation of caspase 9.

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  • Peterson EP, Hudig D, Thornberry NA, Craik CS (1998) Definition and redesign of the extended substrate specificity of granzyme B. J Biol Chem 273: 27364-27373.

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