heart-valve

The most stunning disappointment came 13 years ago, when the widely popular "fen-phen" two-drug combination was pulled off the market after being linked to heart-valve damage and to a rare but potentially deadly lung disease.

Weight-loss drug withdrawal latest blow to obesity fight Rob Stein 2010

The most stunning disappointment came 13 years ago, when the widely popular "fen-phen" two-drug combination was pulled off the market after being linked to heart-valve damage and to a rare but potentially deadly lung disease.

In long quest for diet drug, another setback for obese Rob Stein 2010

A 2003 study in the Journal of the American College of Cardiology followed 220 patients age 65 and older who underwent heart-valve surgery.

Cooking the Books on Grandma's Health Care Betsy McCaughey 2011

Past failures — including the fen-phen combination of the 1990s that led to heart-valve problems in some patients — continue to weigh heavily at the agency.

FDA Rejects Orexigen-Takeda Diet Drug Thomas Gryta 2011

The development of obesity compounds has been a tough area for companies since the fen-phen drug combination was taken off the U.S. market in 1997 after one of the medication's components was linked to heart-valve damage.

FDA Rejects Vivus's Obesity Drug Qnexa Jennifer Corbett Dooren 2010

The FDA has shown a high bar for weight-loss drugs that would be taken indefinitely by millions of patients and the shadow of past failures — including the fen-phen combination that led to heart-valve problems in some patients — serves as a reminder that safety is the primary concern.

New Concerns Emerge About Arena Pharma's Diet Drug Thomas Gryta 2011

The issue of heart-valve safety is notable for lorcaserin because the mechanism of the drug is similar to that of fenfluramine, which was pulled from the market in 1997 and was used with the stimulant phentermine in the fen-phen combination that caused similar problems.

New Concerns Emerge About Arena Pharma's Diet Drug Thomas Gryta 2011

Notably, the FDA also has recommended that Arena expand its studies on the drug's activity on a certain receptor to further assess the risk of heart-valve problems.

New Concerns Emerge About Arena Pharma's Diet Drug Thomas Gryta 2011

Late-stage studies of the drug, including more than 7,000 patients, had statistically ruled out a risk of heart-valve problems in accordance with criteria requested by the FDA, but a smaller study last year showed an imbalance in the problem.

New Concerns Emerge About Arena Pharma's Diet Drug Thomas Gryta 2011

American Home Products faced numerous federal and state suits over the drug, which was later banned for causing heart-valve problems.

Fen-Phen Lawyer's License at Risk Dionne Searcey 2011