Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun chemistry, biochemistry A
trimer , especially a biologically active one, derived from three identicalmonomers
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
Support
Help support Wordnik (and make this page ad-free) by adopting the word homotrimer.
Examples
-
Studies also suggest that HSF1 has intrinsic stress-sensing capacity, as both Drosophila and mammalian HSF1 can be converted from a monomer to a homotrimer in vitro in response to thermal or oxidative stress Previous reports demonstrate that the conversion of HSF1 to the high-affinity DNA binding homotrimer is not robust in neuronal cells
PLoS Biology: New Articles Daniel W. Neef et al. 2010
-
As such, protein chaperones are often referred to as heat shock proteins, or Hsps. Although the mechanisms for HSF1 activation are incompletely understood, a multistep process occurs in response to stress that involves the interconversion of an inactive cytoplasmic monomer to a homotrimer, nuclear accumulation, DNA binding to HSEs, hyperphosphorylation, and target gene.
PLoS Biology: New Articles Daniel W. Neef et al. 2010
Comments
Log in or sign up to get involved in the conversation. It's quick and easy.