Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective organic chemistry Describing any of several classes of compounds derived from
oxoacids by replacing -OH by -NHOH; the N-hydroxy amides
Etymologies
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Examples
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These behavioral improvements were not observed when SAHA (suberoylanilide hydroxamic acid), a selective HDAC inhibitor, was administered.
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For experiments involving suberoylanilide hydroxamic acid (SAHA), the drug was prepared as a 100 mg/ml stock in DMSO.
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The drug suberoylanilide hydroxamic acid (SAHA), originally used to treat lymphoma, was able to restore
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Hu J, Desmond JC, Kawamata N, et al. (2007) Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo.
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Agus DB, Scher HI, Higgins B, Rose A, et al. (2000) Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.
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Injections of sodium valproate, sodium butyrate, or vorinostat (suberoylanilide hydroxamic acid; Zolinza®) completely restored contextual memory in these mutant mice.
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The drug suberoylanilide hydroxamic acid (SAHA), originally used to treat lymphoma, was able to restore
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Pancani T, Formentini L, Mascagni P, Fossati G, et al. (2006) Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.
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Pranpat M, Swaby R, Fiskus W, Yamaguchi H, et al. (2005) Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.
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In lung cells from CF patients, low doses of one inhibitor, suberoylanilide hydroxamic acid (SAHA), already an FDA-approved drug for cancer, gradually restored about 28% of normal channel function and kept it there for up to 10 days after treatment.
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