Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun An antineoplastic drug, CH4N2O2, that suppresses the production of blood cell precursors in the bone marrow and is used in the treatment of certain leukemias, carcinomas, and sickle cell anemia.
from The Century Dictionary.
- noun Same as
hydroxylurea andhydroxylcarbamide .
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry The
hydroxylated derivative ofurea , NH2CO-NHOH, used as anantineoplastic drug ; any N- or O-derivative of this compound
Etymologies
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Examples
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SUNDAY, Dec. 11 HealthDay News -- A drug called hydroxyurea that's approved for use in adults with severe sickle cell anemia can also help young children with the disease, new research suggests.
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This Phase III randomized, multi-center, clinical trial compares standard therapy to prevent repeated stroke and the management of iron overload in pediatric patients (red cell transfusions and iron chelation) with an alternative therapy consisting of the medication, hydroxyurea, combined with phlebotomy, which is the removal of red blood cells.
Sickle cell disease research at The Children's Hospital 2010
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Stroke with transfusions changing to hydroxyurea (SWiTCH)
Sickle cell disease research at The Children's Hospital 2010
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Like methotrexate, hydroxyurea inhibits DNA synthesis cell reproduction thus limiting the effects of psoriasis and other hyperprolific cells such as cancer.
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"The benefits outweigh the risks for hydroxyurea when administered under supervision," said Dr. Lakshmanan Krishnamurti, director of hematology and hemoglobinopathy at Children's Hospital of Pittsburgh.
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In that earlier study, nearly 200 babies between 9 and 18 months old were randomly selected to receive treatment with either hydroxyurea or a placebo.
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All the children had the chance to take hydroxyurea in the follow-up study.
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The study, called Baby Hug, found that children on hydroxyurea had fewer pain crises, acute chest syndrome events, blood transfusions and hospital admissions.
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Some laboratory tests had suggested that this could be possible with hydroxyurea.
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A second study, also to be presented Sunday at the meeting, looked at the potential for a side effect from hydroxyurea called genotoxicity.
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