hypermutations love

Definitions

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  • noun Plural form of hypermutation.

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Examples

  • Moreover hypermutations generated by this enzyme in oncogenes can cause malignancies in haematopoietic cells

    PLoS ONE Alerts: New Articles Vladimir I. Kashuba et al. 2009

  • Importantly, we have also detected hypermutations in other exons of

    PLoS ONE Alerts: New Articles Vladimir I. Kashuba et al. 2009

  • It is reasonable to suggest that other (s) yet unknown DNA polymerase (s) may be responsible for the high mutability rates we report here and more than one polymerase contributes to hypermutations Our results also argue that mutations are not completely random.

    PLoS ONE Alerts: New Articles Vladimir I. Kashuba et al. 2009

  • POLH is expressed in all tissues and, in principle, could cause hypermutations in non-haematopoietic cells.

    PLoS ONE Alerts: New Articles Vladimir I. Kashuba et al. 2009

  • It has been recently shown that the activation-induced cytidine deaminase (AID) is responsible for somatic hypermutations in activated B cells.

    PLoS ONE Alerts: New Articles Vladimir I. Kashuba et al. 2009

  • Somatic hypermutations in tumor suppressor genes involved in major human malignancies offer a novel insight in cancer development, progression and spread.

    PLoS ONE Alerts: New Articles Vladimir I. Kashuba et al. 2009

  • Analysis of microdissected H/RS-like cells revealed their origin as germinal center B cells bearing somatic hypermutations and, in some instances, crippled mutations, as described for human Hodgkin lymphoma (HL).

    PLoS ONE Alerts: New Articles Silke H. Raffegerst et al. 2009

  • The presence of mutations in FR1-FR3 and CDR1-CDR2, in addition to mutations in the CDR3-regions of VDJ-junctions, would indicate that tumor cells originated from mature, activated B cells of germinal centers with ongoing somatic hypermutations (SHM).

    PLoS ONE Alerts: New Articles Silke H. Raffegerst et al. 2009

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