Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Of, pertaining to, or causing
hypomethylation
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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A bone marrow transplant is the only known potential cure, but older patients, such as the ones in the Cyclacel study, are often not candidates for a transplant and are typically treated with so-called hypomethylating agents.
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SGI-110, SuperGen's second-generation hypomethylating agent and follow-on to Dacogen, is proceeding well in patient accrual in its current Phase I/II MDS and AML trial.
unknown title 2011
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"Its preclinical anticancer and hypomethylating effects have been observed in both hematological and solid tumors models."
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Approximately 16% were previously treated with lenalidomide in addition to hypomethylating agents.
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"SGI-110 is a low volume, easy to administer, subcutaneous drug with a pre-clinical profile that has demonstrated potent hypomethylation and epigenetic modulation with less frequent administration than currently marketed hypomethylating agents," said Mohammad Azab, M.D.
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We plan to initiate discussions with the FDA regarding potential registration pathways in MDS patients refractory to hypomethylating agents.
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The study enrolled 61 patients aged 60 or older with MDS refractory to hypomethylating agents randomized across three dosing schedules of sapacitabine: 21 patients in Arm A, a 7-day low dose regimen (200 mg b.i.d.); 20 patients in Arm B, a 7-day high dose regimen (300 mg b.i.d.) and 20 patients in Arm C, a 3-day high dose regimen (400 mg b.i.d.)
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MDS patients have a poor outcome after treatment failures of hypomethylating agents.
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All patients were previously treated with hypomethylating agents:
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Myelodysplastic syndrome patients have a poor outcome after treatment failures of hypomethylating agents.
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