Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun genetics a
decrease in theepigenetic methylation ofcytosine andadenosine residues inDNA
Etymologies
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Examples
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The so-called hypomethylation of the AVP enhancer region was specific to an area of the brain that is intimately involved in stress related hormone release.
Uncommon Descent 2009
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However, separate analyses in the same study showed that pancreatic cancers with reduced MTHFR function due to loss of an MTHFR allele had more DNA hypomethylation and more chromosomal deletions.
Meat diet reduces risk of pancreatic cancer | The Blog of Michael R. Eades, M.D. 2007
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DNA hypomethylation after 5-Azacytidine treatment.
PLoS ONE Alerts: New Articles Yongguang Tao et al. 2010
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This information is useful for understanding natural status of Alu in the genome and helpful for developing an optimal assay to quantify Alu hypomethylation.
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DNA hypomethylation after 5-Azacytidine treatment.
PLoS ONE Alerts: New Articles Yongguang Tao et al. 2010
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Global DNA hypomethylation was reported in a population exposed to benzene, but has not been confirmed in vitro.
Naturejobs - All Jobs Z Ji 2010
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Alu hypomethylation in primary gastric carcinomas could be detected with the Cac8I COBRA-DHPLC assay quantitatively.
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HQ induced global DNA hypomethylation at a level intermediate to melphalan (no effect) and etoposide (potent effect).
Naturejobs - All Jobs Z Ji 2010
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Validation studies showed that hypermethylation or hypomethylation of Alu elements in human cell lines could be detected sensitively by the assay after treatment with 5-aza-dC and M. SssI, respectively.
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In addition to cytogenetic changes, global DNA hypomethylation may be another mechanism underlying the leukemogenicity of benzene.
Naturejobs - All Jobs Z Ji 2010
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