hypophyseal

Once in the pituitary, they determine the exact quantities of the various hypophyseal hormones which must be produced at a given point in time.

The Nobel Prize in Physiology or Medicine 1977 - Presentation Speech 1992

At this stage even if the hypophyseal treatment is discontinued the animals remain permanently diabetic, degeneration of the beta cells continues and the pancreas ceases to secrete insulin.

Bernardo Houssay - Nobel Lecture 1964

They are not due exclusively to hyperglycemia as proved by the fact that the same levels of blood sugar have been maintained during four days by continuous injection of glucose and by hypophyseal extracts injections.

Bernardo Houssay - Nobel Lecture 1964

Thus as the mass of the pancreas is progressively reduced by extirpation of increasingly larger portions, the dose of hypophyseal extract needed to provoke diabetes diminishes.

Bernardo Houssay - Nobel Lecture 1964

Extrapancreatic: factors are demonstrated by: (1) the diabetogenic effect obtained in pancreatectomized hypophysectomized animals; (2) the increase in the severity of diabetes in pancreatectomized dogs treated with anterohypophyseal extract; (3) the increase in resistance to insulin which precedes and accompanies hypophyseal diabetes; (4) the fact that hyperglycemia and diabetes occur before that there are visible lesions in the beta cells of the islets, and before insulin secretion diminishes.

Bernardo Houssay - Nobel Lecture 1964

It is possible that in acromegaly, in some stages of the disease there may be a hypophyseal diabetes and at others a metahypophyseal diabetes.

Bernardo Houssay - Nobel Lecture 1964

The diabetic conditions which persists when the hypophyseal treatment is discontinued, should be called metahypophyseal diabetes.

Bernardo Houssay - Nobel Lecture 1964

Hepatectomy causes a rapid fall in the blood sugar of dogs or toads with a hypophyseal diabetes.

Bernardo Houssay - Nobel Lecture 1964

A normal pancreas reestablishes the normal blood sugar level in three to five hours and maintains it there, while the pancreas taken from an animal in hypophyseal diabetes has little or no effect on the blood sugar.

Bernardo Houssay - Nobel Lecture 1964

The injection or implantation of anterior hypophyseal lobe reestablished or even increased the usual severity of diabetes.

Bernardo Houssay - Nobel Lecture 1964