from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun A tricyclic compound, C19H24N2, used to treat depression and enuresis.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun chemistry a tricyclic heterocyclic compound used to treat depression

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression


from The American Heritage® Dictionary of the English Language, 4th Edition

[imi(ne) + pr(opyl) + amine.]


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  • His data was overwhelming, his enthusiasm even stronger, but G22355—by then known as imipramine—was hardly taking the world by storm, and Kuhn was roundly ignored.


  • Finally, he experienced some relief when he switched to an old-fashioned tricyclic antidepressant called imipramine.

    The Full Feed from

  • The other showed that an antidepressant called imipramine, which was known to block NPC1, seemed to prevent infection as well.

    NYT > Home Page

  • A class of older antidepressants called tricyclics, such as amitriptyline (Elavil) or imipramine (Tofranil), are effective at staving off chronic tension-type headaches in many people who have not found relief with over-the-counter medications.

    Case of the Daily Headache

  • This “vital disturbance,” Kuhn claimed, is what imipramine was uniquely suited to treat.


  • Endogenous depression was exactly the disease that imipramine cured, and the proof that you had been sick was that imipramine cured you.


  • The studies showed that this was true, whether or not the patients took Paxil, a selective serotonin reuptake inhibitor (SSRI), or imipramine, a tricylcic, an older generation of anti-depressant medication.

    Robert David Jaffee: Medication Can Help The Severely Depressed

  • And when Axelrod showed that imipramine worked the latter way, blocking the reuptake of norepinephrine, it was easy to believe that the catecholamine hypothesis was correct.


  • Amphetamines only made you feel better, but imipramine made you feel well—which meant that you must have been sick all along.


  • At a time when psychoanalysis was the mainstay of psychiatry, he was arguing that imipramine could “bring a complete change in the situation within a few days, which could not be achieved by intensive prolonged psychotherapy.”



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