Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A tricyclic compound, C19H24N2, used to treat depression and enuresis.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun chemistry a
tricyclic heterocyclic compound used to treatdepression
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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His data was overwhelming, his enthusiasm even stronger, but G22355—by then known as imipramine—was hardly taking the world by storm, and Kuhn was roundly ignored.
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Finally, he experienced some relief when he switched to an old-fashioned tricyclic antidepressant called imipramine.
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The other showed that an antidepressant called imipramine, which was known to block NPC1, seemed to prevent infection as well.
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A class of older antidepressants called tricyclics, such as amitriptyline (Elavil) or imipramine (Tofranil), are effective at staving off chronic tension-type headaches in many people who have not found relief with over-the-counter medications.
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This “vital disturbance,” Kuhn claimed, is what imipramine was uniquely suited to treat.
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Endogenous depression was exactly the disease that imipramine cured, and the proof that you had been sick was that imipramine cured you.
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The studies showed that this was true, whether or not the patients took Paxil, a selective serotonin reuptake inhibitor (SSRI), or imipramine, a tricylcic, an older generation of anti-depressant medication.
Robert David Jaffee: Medication Can Help The Severely Depressed
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And when Axelrod showed that imipramine worked the latter way, blocking the reuptake of norepinephrine, it was easy to believe that the catecholamine hypothesis was correct.
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Amphetamines only made you feel better, but imipramine made you feel well—which meant that you must have been sick all along.
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At a time when psychoanalysis was the mainstay of psychiatry, he was arguing that imipramine could “bring a complete change in the situation within a few days, which could not be achieved by intensive prolonged psychotherapy.”
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