Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Of or pertaining to the
epitope of amolecule thatprovokes the mostintense immune response
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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To test the involvement of immunoproteasome and its LMP2 R60H polymorphism in MS we investigated one of the major immunodominant self-epitopes detected in MS patient blood
PLoS ONE Alerts: New Articles Michele Mishto et al. 2010
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Valmori D, Fonteneau JF, Lizana CM, Gervois N, Lienard D, et al. (1998) Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues.
PLoS ONE Alerts: New Articles Michele Mishto et al. 2010
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Accordingly, immunoproteasomes carrying the LMP2 60H allele produce in vitro a lower amount of the HLA-A*0201 restricted immunodominant epitope MBP The immunoproteasome LMP2 60HH variant reduces the risk to develop MS amongst Italian HLA-A*02+ females.
PLoS ONE Alerts: New Articles Michele Mishto et al. 2010
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However, identification of immunodominant antigens to enable accurate measurement of protective responses - and to potentially develop immunotherapies - has been elusive.
PLoS ONE Alerts: New Articles Neelkamal Chaudhary et al. 2010
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Kawakami Y, Eliyahu S, Sakaguchi K, Robbins PF, Rivoltini L, et al. (1994) Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.
PLoS ONE Alerts: New Articles Virginie Renaud et al. 2010
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BenMohamed L, Bertrand G, McNamara CD, Gras-Masse H, Hammer J, et al. (2003) Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity.
PLoS ONE Alerts: New Articles Christopher R. Cotter et al. 2010
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Accordingly, immunoproteasomes carrying the LMP2 60H allele produce in vitro a lower amount of the HLA-A*0201 restricted immunodominant epitope MBP
PLoS ONE Alerts: New Articles Michele Mishto et al. 2010
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Ohnishi M, Sakurai T, Heike Y, Yamazaki R, Kanda Y, et al. (2005) Evaluation of cytomegalovirus-specific T-cell reconstitution in patients after various allogeneic haematopoietic stem cell transplantation using interferon-gamma-enzyme-linked immunospot and human leucocyte antigen tetramer assays with an immunodominant T-cell epitope.
PLoS ONE Alerts: New Articles Neelkamal Chaudhary et al. 2010
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A possible reason is that these are immunodominant responses captured at a particular timepoint and which wane with continuing viral replication.
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We next sought to determine whether the most immunodominant peptides in clade C and clade B infection are cross-recognized.
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