inflammasome

Figure 3: The M2 channel activity of influenza virus is required for inflammasome activation.

Naturejobs - All Jobs Takeshi Ichinohe 2010

This is the first time that the involvement of the inflammasome complexes was shown in MKD pathogenesis.

Naturejobs - All Jobs Alessandra Pontillo 2010

Here we show that the influenza virus M2 protein, a proton-selective ion channel important in viral pathogenesis, stimulates the NLRP3 inflammasome pathway.

Naturejobs - All Jobs Takeshi Ichinohe 2010

Figure 1: Influenza viruses are specifically able to induce inflammasome activation.

Naturejobs - All Jobs Takeshi Ichinohe 2010

Figure 5: M2 is sufficient to trigger signal 2 for inflammasome activation.

Naturejobs - All Jobs Takeshi Ichinohe 2010

Influenza virus, a negative-stranded RNA virus that causes severe illness in humans and animals, stimulates the inflammasome through the Nod-like receptor NLRP3.

Naturejobs - All Jobs Takeshi Ichinohe 2010

In this study, researchers showed IL-18 produced by the Nlrp3 inflammasome helped mice maintain healthy colon by triggering production of more epithelial cells to compensate for those damaged or destroyed by colitis.

Medindia Health News 2010

Nlrp3 works by anchoring a large, multi-protein complex known as the Nlrp3 inflammasome where the messenger protein interleukin 18 (IL-18) is made.

Medindia Health News 2010

The missing link: how the inflammasome senses oxidative stress

Naturejobs - All Jobs Chengcheng Jin 2010

However, the mechanism by which influenza virus activates the NLRP3 inflammasome is unknown.

Naturejobs - All Jobs Takeshi Ichinohe 2010