insertional

Inserting foreign or transgenes is called insertional mutagenesis or insertion mutation.

Potential Health Hazards of Genetically Engineered Foods 2008

Inserting foreign or transgenes is called insertional mutagenesis or insertion mutation.

Potential Health Hazards of Genetically Engineered Foods 2008

Phylogenetic analyses showed that EBLNs seem to have been generated by different insertional events in each specific animal family.

A New Wrinkle on Parasitic Elements 2010

For example, SINES and LINES can cause insertional mutagenesis, hybrid dysgenesis, chromosomal rearrangements, etc.

Junk DNA, Junk Science, and The Onion Test - The Panda's Thumb 2007

Despite the fact that viral vectors have proven to be effective tools for reprogramming, the resulting iPSC clones usually display several proviral integrations, ultimately increasing the risk of insertional mutagenesis.

BioMed Central - Latest articles Cesar Sommer 2010

A feasible way to decrease the risk of insertional mutagenesis is to combine the reprogramming factors into a single polycistronic vector by inserting a 'self-cleaving' 2A peptide or an internal ribosome entry site (IRES) sequence between two consecutive open reading frames.

BioMed Central - Latest articles Cesar Sommer 2010

The team's six years of experience performing HT RNAi screens with pooled lentiviral shRNA libraries designed for HT sequencing, HT screening for bioactive peptides, HT functional validation of shRNA, stable cell line development, and HT insertional mutagenesis has resulted in some of the most advanced technologies available, developed in collaboration with opinion leaders and with funding from nine NIH SBIR grants.

PRWeb - Daily News Feed 2010

Krm2 over-expression and not caused by an insertional inactivation of other genes.

PLoS ONE Alerts: New Articles Jochen Schulze et al. 2010

Other insertional variants of the humanized anti-IL-10 antibody molecule include the fusion to the N - or C-terminus of humanized anti-IL-10 antibody of an enzyme or a polypeptide which increases the serum half-life of the antibody.

FreshPatents.com: Notable Patent Applications - 07/22/2010 2010

These approaches, however, do not completely eliminate the theoretical risk of insertional mutagenesis since approximately 200 base pairs of exogenous

BioMed Central - Latest articles Cesar Sommer 2010