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Examples
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One drug that promises to do this is interleukin-7.
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Robert Murphy of Northwestern University, in Illinois, who is leading one of the clinical trials, says blips of reawakened virus can indeed be seen in patients' blood after a dose of interleukin-7.
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The idea is that a dose of interleukin-7 will nudge the T-cell-and therefore the virus-into wakefulness.
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Cytheris broadens patent protection for recombinant human interleukin-7
THE MEDICAL NEWS Editors 2010
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Baltus B, Vondenhoff M, Huizinga TW, Tak PP, et al. (2007) Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis.
PLoS ONE Alerts: New Articles Gang Wu et al. 2010
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WQ, Hofmeister RR, Young HA, Hodge DR, et al. (2004) Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members.
PLoS ONE Alerts: New Articles Ryan M. O'Connell et al. 2010
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E, Falloon J, Lederman MM, Liewehr DJ, et al. (2001) A potential role for interleukin-7 in T-cell homeostasis.
PLoS ONE Alerts: New Articles Ryan M. O'Connell et al. 2010
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Cytheris broadens patent protection for recombinant human interleukin-7
THE MEDICAL NEWS Editors 2010
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Y, Ogura H, Kitabayashi C, Jiang JJ, et al. (2009) Hepatic interleukin-7 expression regulates T cell responses.
PLoS ONE Alerts: New Articles Ryan M. O'Connell et al. 2010
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Testing of various conditions revealed that reduction of the cytokine interleukin-7 (IL-7), possibly corresponding to an environmental signal in the thymus, triggered resumption of development and differentiation into T cells.
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