isochore

Comparison of the cumulative isochore distribution on chromosomes 17 to 22 and on the whole human genome.

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009

Our results show that insertions and deletions are almost absent in L1 and generally scarce in L2 isochore families (GC-poor L1+L2 isochores represent slightly over half of the human genome), whereas they increase in GC-rich isochores, largely paralleling the densities of genes, retroviral integrations and

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009

The isochore distribution of the whole human genome is from ref.

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009

The results in terms of numbers of insertions/deletions located in different isochore families are reported in

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009

In order to compare the two histograms, isochore frequencies were calculated as percentages of the total.

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009

In sharp contrast with insertions/deletions, the densities of SNPs were largely uniform over all isochore families

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009

The slightly different amounts of DNA in isochore families between (A) and (B) are related to the fact that deletions in Venter's chromosomes are seen as insertions in the reference chromosomes, and the latter are slightly different from Venter's chromosomes because of insertions and deletions.

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009

The densities of insertions/deletions in chromosomes 17 to 22 are reported for the five isochore families.

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009

The distributions of insertions/deletions are in striking contrast with those of SNPs which exhibit almost the same density across all isochore families with, however, a trend for lower concentrations in gene-rich regions.

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009

The locations of insertions and deletions, respectively, in the isochore families of Venter's chromosomes 17 to 22 are summarized in

PLoS ONE Alerts: New Articles Maria Costantini et al. 2009