isomorphous

It was a technique invented by J.M. Robertson at Glasgow University for small organic molecules, known as the isomorphous replacement method.

The Nobel Prize in Chemistry 1962 - Perspectives 1962

For any attempt to resolve the issue by pronouncing the work of critique to be wholly isomorphous with the contingent material experiences that gave rise to it or, alternatively, as sublating (aufheben) aesthetic experience into pure abstractions invariably forecloses on the ethical implications of critical practice.

Pfau, Coda & Works Cited' 1999

On the other hand, though my introduction of the method of isomorphous replacement with heavy atoms had made the solution of protein structures possible in principle, none had yet been solved.

The Medical Research Council Laboratory of Molecular Biology 1997

During the eighties I initiated work on the problem of combining the traditional techniques of direct methods with isomorphous replacement and anomalous dispersion in the attempt to facilitate the solution of macromolecular crystal structures.

Herbert A. Hauptman - Autobiography 1986

It can also incorporate information from isomorphous replacement measurements.

Jerome Karle - Autobiography 1986

Later, we also grew crystals of potassium and rubidium benzyl-penicillin, hoping again for isomorphous series.

Nobel Lecture The X-Ray Analysis Of Complicated Molecules 1964

But first the sodium salt was not isomorphous with the other two, then the potassium and rubidium ions were in such positions in the structure that they did not contribute to many of the reflections.

Nobel Lecture The X-Ray Analysis Of Complicated Molecules 1964

As Perutz and Kendrew explained, the introduction of additional heavy atoms into a crystal under investigation at sites which can be found, may make it possible to calculate phase angles directly from the observed amplitudes of the spectra given by the isomorphous crystals.

Nobel Lecture The X-Ray Analysis Of Complicated Molecules 1964

The crystal structures of cholesteryl chloride and bromide proved not sufficiently isomorphous to solve by direct-phase determination.

Nobel Lecture The X-Ray Analysis Of Complicated Molecules 1964

Rochelle salt, isomorphous replacement and phase determination, metal crystals and pepsin crystals, and speculated about muscular contraction.

Nobel Lecture The X-Ray Analysis Of Complicated Molecules 1964