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Also, the kinase inhibitor kenpaullone was found to replace Klf4 , although the underlying mechanism is unknown at present.
The screening process identified two tiny molecules, kenpaullone and roscovitine, which only weakly bind to hPXR but strongly activate its signaling pathway.
Chen's team found that in addition to this weak binding to hPXR, kenpaullone and roscovitine can inhibit a group of enzymes known as cyclin-dependent kinases (Cdks).