Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry A selective
proteosome inhibitor found inStreptomyces bacteria .
Etymologies
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Examples
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Here's the question: Just found out that lactacystin is an inhibitor of proteosome activity and may therefore be related to experimentally induced Alzheimers.
Not all "Lact" Words Are the Same Steve Carper 2008
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The cleavage of GAD67 was sensitive to the proteasome inhibitors MG132, YU102 and lactacystin, and was also abrogated by the E1 ubiquitin ligase inhibitor UBEI-41.
Elites TV PLoS ONE 2010
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Therefore, three proteasomal inhibitors, MG132, clasto-lactacystin β-lactone and epoxomicin, were tested for their ability to suppress the ENC1-induced decrease in Nrf2 expression.
PLoS ONE Alerts: New Articles Xiao-Jun Wang et al. 2009
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Yew EH, Cheung NS, Choy MS, Qi RZ, Lee AY, et al. (2005) Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis.
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The aim of this project is to establish a rapid and efficient total synthesis of the proteolytic enzyme inhibitors lactacystin, PS-519, the core structure of
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Transfected cells were treated with proteasome inhibitors MG132 (M) (10 µM), clasto-lactacystin β-lactone (Lac) (10 µM) or epoxomicin (Ep) (1 µM), or lysosome inhibitors chloroquine (Ch) (50 µM) or ammonium chloride (Ac) (50 mM) for 4 hr before cells were lysed at
PLoS ONE Alerts: New Articles Xiao-Jun Wang et al. 2009
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Similar levels of induction were observed when clasto-lactacystin β-lactone or epoxomicin was used (
PLoS ONE Alerts: New Articles Xiao-Jun Wang et al. 2009
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