lactams

In fact, the recruitment of similar resistance determinants within a single P. aeruginosa strain can determine a resistance phenotype to virtually all the available antipseudomonal beta-lactams, an occurrence that can be particularly dramatic when, as in the present case, resistance to beta-lactams is associated with resistance against aminoglycosides and fluoroquinolones. link (emphasis mine)

Behe's Test 2008

PFGE, the molecular-fingerprint technique, had not been invented yet,14 but the MRSA strains in the addicts and in the Henry Ford patients were resistant to exactly the same medications: methicillin and all the beta- lactams, and two additional classes of drugs.

SUPERBUG MARYN MCKENNA 2010

In Pseudomonas aeruginosa, secondary beta-lactamases with extended substrate specificity can be responsible for acquired resistance to the most powerful antipseudomonal beta-lactams, such as expanded-spectrum cephalosporins and carbapenems.

Behe's Test 2008

PFGE, the molecular-fingerprint technique, had not been invented yet,14 but the MRSA strains in the addicts and in the Henry Ford patients were resistant to exactly the same medications: methicillin and all the beta- lactams, and two additional classes of drugs.

SUPERBUG MARYN MCKENNA 2010

The strain must have been in pigs for a while, because in addition to methicillin and the rest of the beta–lactams, it was also resistant to tetracycline.

SUPERBUG MARYN MCKENNA 2010

The strain must have been in pigs for a while, because in addition to methicillin and the rest of the beta–lactams, it was also resistant to tetracycline.

SUPERBUG MARYN MCKENNA 2010

The strain must have been in pigs for a while, because in addition to methicillin and the rest of the beta–lactams, it was also resistant to tetracycline.

SUPERBUG MARYN MCKENNA 2010

PFGE, the molecular-fingerprint technique, had not been invented yet,14 but the MRSA strains in the addicts and in the Henry Ford patients were resistant to exactly the same medications: methicillin and all the beta- lactams, and two additional classes of drugs.

SUPERBUG MARYN MCKENNA 2010

Even with related substrates, some showed big changes others little, so without a good panel of beta-lactams to check the function of the crippled enzyme, the functional space represented is under sampled.

Axe (2004) and the evolution of enzyme function - The Panda's Thumb 2007

Antibiotics such as penicillin are called, collectively, beta-lactams, and enzymes that break down these antibiotics and confer drug resistance are called beta-lactamases, which is why the term beta-lactamase may pop up in this blog entry from time to time.

Axe (2004) and the evolution of enzyme function - The Panda's Thumb 2007