Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- abbreviation genetics long non-coding RNA
Etymologies
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Examples
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Bottom: magnified view of the lincRNA locus showing the coverage of H3K4me3 (green track), H3K36me3 (blue track) and RNA-Seq reads (red track) overlapping the transcribed lincRNA locus, as well as its Scripture reconstructed transcript isoforms (black).
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We then determined the gene structures of more than a thousand large intergenic noncoding RNA (lincRNA) and antisense loci.
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Shown is the cumulative distribution of sequence conservation across 29 mammals for exons from protein coding exons, introns, exons from previously annotated lincRNA loci, exons from newly annotated lincRNA transcripts and exons from multi-exonic antisense transcripts.
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Top: mouse genomic locus containing the lincRNA and its neighboring protein coding genes.
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We also developed a functional genomics approach that assigns putative functions to each lincRNA, demonstrating a diverse range of roles for lincRNAs in processes from embryonic stem cell pluripotency to cell proliferation.
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Because of the stringent experimental conditions imposed by the researchers in identifying the 1,600 lincRNAs in the Nature study, it is likely that there are many more lincRNA genes hiding in plain sight in the genome, as well as other RNA-encoding genes that are as important to genome function as their better-recognized protein-coding counterparts.
Biosingularity 2009
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This provides functional confirmation that this lincRNA has a direct role in cell proliferation in ESCs, consistent with the analysis above.
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We also developed a functional genomics approach that assigns putative functions to each lincRNA, demonstrating a diverse range of roles for lincRNAs in processes from embryonic stem cell pluripotency to cell proliferation.
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We also developed a functional genomics approach that assigns putative functions to each lincRNA, demonstrating a diverse range of roles for lincRNAs in processes from embryonic stem cell pluripotency to cell proliferation.
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Because of the stringent experimental conditions imposed by the researchers in identifying the 1,600 lincRNAs in the Nature study, it is likely that there are many more lincRNA genes hiding in plain sight in the genome, as well as other RNA-encoding genes that are as important to genome function as their better-recognized protein-coding counterparts.
PhysOrg.com - latest science and technology news stories 2009
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