Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Pertaining to, or causing
lipotoxicity
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Therefore, this may explain why short-term feeding of the high-E/N diet was not sufficient to reduce lipotoxic lipids to the point where peripheral insulin resistance was restored.
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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"Future research will explore potential inflammatory and lipotoxic pathways by which intermittent hypoxia disrupts glucose and insulin homeostasis."
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Thus, the reduction of lipotoxic lipids could be one of the major pathways by which the high-KAA diet maintains muscle AMPK and extrahepatic substrate utilization. ob/ob mice that had already developed noticeable insulin resistance and hepatic steatosis before KAA treatment.
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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Because lipotoxic metabolites such as ceramides and diacylglycerols (DAGs) are believed to be responsible for HFD-induced insulin resistance
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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A few studies along these lines suggested a causal relationship between lipotoxic metabolites and decreased AMPK phosphorylation
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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Effect of high-KAA diet on the production of hepatic and muscular lipotoxic metabolites.
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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Although it was not clear why the high-E/N diet did not affect postprandial insulin levels in ob/ob mice, muscle lipotoxic lipids were considerably higher before KAA treatments than those in high-fat treated C57B6 mice.
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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Effects of high-KAA diet on hyperinsulinemia and lipotoxic metabolite synthesis
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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Thus, we hypothesize that if muscle is protected from accumulation of lipotoxic lipids, peripheral insulin resistance and postprandial hyperinsulinemia will improve.
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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In particular, elevated concentrations of "lipotoxic lipids" such as diacylglycerols and ceramides have been recognized as factors contributing to impaired insulin signaling in non-adipose tissues
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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