Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun pathology The result of the accumulation of
lipids intissue other thanadipose tissue
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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However, the toxic effect of FFAs on the pancreatic β-cells, originally termed lipotoxicity, gains pathological significance mainly under the
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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More information: Scherer et al.: "Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. '"
PhysOrg.com - latest science and technology news stories PhysOrg Team 2010
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Thus, muscle appears to be more susceptible to lipotoxicity than liver, and readily develops an insulin resistant state.
PLoS ONE Alerts: New Articles Yasushi Noguchi et al. 2010
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Our study tested the hypothesis that glucose augments lipotoxicity by stimulating mTORC1 leading to increased β-cell ER stress.
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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Poitout V, Robertson RP (2002) Minireview: secondary beta-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxicity.
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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Why glucose exacerbates β-cell lipotoxicity is largely unknown.
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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Herein we tested the hypothesis that glucose augments lipotoxicity by stimulating mTORC1, thus leading to increased FFA-induced ER stress, with augmentation of β-cell apoptosis as a consequence.
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, et al. (2007) PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.
PLoS Biology 2008
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Unger concludes his review article this way: "Based on evidence reviewed here, it seems that prevalent forms of metabolic syndrome and T2DM [type 2 diabetes mellitus] result from unremitting caloric surplus complicated by failure of adipocytes to maintain protection against lipotoxicity.
PhysOrg.com - latest science and technology news stories PhysOrg Team 2010
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Ectopic deposition of lipids in organs other than adipose tissue is believed to cause insulin resistance via lipid-induced toxicity, or lipotoxicity (see
PLoS Biology 2008
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