Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Plural form of
macropinosome .
Etymologies
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Examples
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Upon endocytosis, early uPAR-enriched macropinosomes might acquire regulatory proteins such as EEA1 and fuse with pre-existing early / sorting endosomes.
PLoS ONE Alerts: New Articles Katia Cortese et al. 2008
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Consistent with this notion, our experiments using PrP-Cre reporter fusion proteins as a phenotypic marker of endosomal escape suggest that, at least, a small proportion of extracellular PrP that is internalized can escape from macropinosomes into the cytoplasm.
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In addition, fusion of the cationic N-terminal PrP domain to a Cre recombinase reporter protein was sufficient to promote both cellular uptake and escape from the macropinosomes into the cytoplasm.
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