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  • noun biochemistry Any enzyme that catalyses the hydrolysis of mannose glycosides.


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  • Kuntz DA, Rose DR, Pinto BM (2005) A combined STD-NMR/molecular modeling protocol for predicting the binding modes of the glycosidase inhibitors kifunensine and salacinol to Golgi alpha-mannosidase II.

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  • Activity on 4-MeUMB-Man was greater, permitting full Michaelis-Menten kinetics and allowing description of the SpGH38 as an α − mannosidase with a kcat of 1. 8±0.24 min − 1 and K.

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  • Furthermore, mouse knock-outs show that mannosidase II deficient animals suffer from lupus-like auto immune diseases

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  • Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.

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  • Kuntz DA, Ernber B, Singh H, Moremen KW, et al. (2008) Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant.

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  • Here we show that the Streptococcus pyogenes (M1 GAS SF370) GH38 enzyme (Spy1604; hereafter SpGH38) is an α − mannosidase with specificity for α − 1,3 mannosidic linkages.

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  • Drosophila GH38 α − mannosidase II, which has been shown to be a retaining α − mannosidase that targets both α − 1,3 and α − 1,6 mannosyl linkages, an activity that enables the enzyme to process GlcNAc (Man) 5 (GlcNAc) 2 hybrid N-glycans to GlcNAc (Man) 3 (GlcNAc) 2.

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  • The two enzymes, 'alpha-man' (alpha-mannosidase) and 'beta hex' (beta delta N-acetylhexosaminidase), are specifically linked to fruit softening that happens during ripening.


  • One possible role for the GH38 α − mannosidase and GH84 β − GlcNAcase enzymes might therefore be in the subsequent intracellular utilization of The sequence of full length S. pyogenes α-mannosidase II, coding for SpGH38 residues

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  • We have shown that The S. pyogenes ORF spy1604 encodes an α − 1,3 mannosidase that is active on disaccharides, some aryl glycosides and can also effectively deglycosylate human

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