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minimal change disease

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  • The cause of minimal change disease is not fully known but it is believed to be an immune disorder in which T cells release a cytokine that damages the epithelial foot processes of the glomeruli. This leads to a leakage of albumin by the kidney. Certain events such as a viral infection, an allergic reaction, a bee sting, or an immunization may trigger an attack of MCD.

    Minimal change disease is the most common form of the nephrotic syndrome in children aged 2 to 12 years. It is the cause of nephrotic syndrome in about 90% of children younger than 10 years, about 50% to 70% of older children, and 10% to 15% of adults.

    March 23, 2016