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Examples
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It is patients with multibacillary forms of leprosy (BL and LL) who are most exposed to the risk of drug resistance and who are also most infectious to their household contacts.
Chapter 9 1993
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We also carried out tests of heterogeneity of the associations (or lack thereof) between these 93 SNPs and disease, stratified according to clinical subtype (multibacillary vs. paucibacillary).
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C13orf31, LRRK2, NOD2, and RIPK2 and multibacillary leprosy were stronger than the associations between these SNPs and paucibacillary leprosy.
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We also carried out tests of heterogeneity of the associations (or lack thereof) between these 93 SNPs and disease, stratified according to clinical subtype (multibacillary vs. paucibacillary).
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C13orf31, LRRK2, NOD2, and RIPK2 and multibacillary leprosy were stronger than the associations between these SNPs and paucibacillary leprosy.
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IFNγR1 deficiency Complete IFNγR1 deficiency - loss of expression of receptor at cell surface - BCG infection and environmental mycobacteria - majority of patients death before 3 yrs old - other infection = > non-typhoidal salmonella, Listeria, some viral infection (rare, individual pts.) - pathology multibacillary, poorly organized granuloma - prognosis is poor - Therapeutic option is BMT
Recently Uploaded Slideshows AllergyChula 2009
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