Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any agent that
mimics the biological activity ofphosphate
Etymologies
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Examples
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In addition, these phosphomimetic mutants appear to inhibit CCCP-induced recruitment of Parkin.
PLoS Biology: New Articles Derek P. Narendra et al. 2010
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Specifically, they replaced the S13 and S16 with phosphomimetic aspartate (SD) or phosphoresistant alanine (SA).
PhysOrg.com - latest science and technology news stories 2009
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Mice with the phosphoresistant version of the protein developed symptoms of Huntington's, but mice with the phosphomimetic version remained free of symptoms and huntingtin clumps up to one year.
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Meanwhile, test tube experiments by Dr. Wetzel's group in Pittsburgh showed that phosphomimetic modification of a huntingtin fragment reduced its tendency to form clumps.
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Dr. Yang said he plans to examine older mice carrying the phosphomimetic version of mutant huntingtin to determine how long they are protected from the disease.
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The nearly complete lack of any signs of disease in the phosphomimetic Huntington mice may point toward new strategies to treat the disorder someday.
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Through further genetic engineering, Dr. Yang altered the same two critical amino acids at the end of the mutant huntingtin protein to either mimic phosphorylation (phosphomimetic) or resist it (phosphoresistant).
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They generated flies in which they mutated the endogenous Tsc2 gene and simultaneously expressed either a wildtype Tsc2 or a mutant Tsc2 in which all four Akt phosphorylation sites were mutated to alanine or to a phosphomimetic residue.
PLoS ONE Alerts: New Articles Sibylle Schleich et al. 2009
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S533A) or phosphomimetic (Tsc1S533D) residues, and show that in both cases the flies are rescued to full viability and size.
PLoS ONE Alerts: New Articles Sibylle Schleich et al. 2009
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