Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Of or pertaining to
plasma cells
Etymologies
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Examples
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Normally, a subset of immune cells called plasmacytoid dendritic cells pDCs recognize HIV quickly and react by producing signaling molecules called interferons.
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They found that pulse doses of intravenous steroids kill off the cells - called plasmacytoid dendritic cells - producing interferon alpha, a protein that promotes this inflammation.
PhysOrg.com - latest science and technology news stories 2010
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Washington, September 7: An Indian-origin researcher at New York University says that she has gained fresh insights into the role of human immune cells known as plasmacytoid dendritic cells (pDCs) in the anti-HIV immune response.
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CD4 Binding affinity determines HIV-1 induced plasmacytoid dendritic cell interferon alpha production.
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The most significant finding of the Japanese study was identification of a rare immune system cell type, dendritic, or plasmacytoid, plasma cells, which control the effect of inactivated flu virus vaccines, Ishii said.
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Human plasmacytoid dendritic cells (hu-pDCs) were directly isolated from the peripheral blood mononuclear cell (PBMC) fraction after Ficoll density separation of Buffy coats using BDCA4 (CD304) + antibody labeled magnetic beads and elution through iron-based MidimacsLS columns (MIltenyi Biotec).
PLoS ONE Alerts: New Articles Christopher R. Cotter et al. 2010
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In preclinical studies, IMO-2125 induced high levels of endogenous interferon-alpha and Th1-type cytokines and chemokines in human peripheral blood mononuclear cells (PBMCs) and plasmacytoid dendritic cells (pDCs) (data presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 2007, Abstract 2714).
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Interestingly, while vhs is capable of inhibiting the release of cytokines during infection of human and mouse cDCs, the secretion of cytokines by plasmacytoid DC (pDC) is not affected by vhs.
PLoS ONE Alerts: New Articles Christopher R. Cotter et al. 2010
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In vitro analysis has demonstrated that PCV2 accumulates in monocytic cells, particularly the plasmacytoid dendritic cell (DC), for prolonged periods of time but the virus does not replicate substantially within these cells.
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Moreover, through its modulation of the innate immune response, specifically the impairment of interferon alpha and tumour necrosis factor alpha production in some plasmacytoid DC, PCV2 infection eventually induces immunosuppression and may render the host more susceptible to secondary infections.
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