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- noun Plural form of
Sorry, no etymologies found.
Knockout of plasmepsins I-IV, the 4 known food vacuole plasmepsins, was not lethal to P. falciparum (although parasites with knockout of all four food vacuole plasmepsins demonstrated abnormal development)  appears to be lethal, arguing for essential functions for these enzymes, although it is not known if the essential functions are hydrolysis of hemoglobin.
Bonilla JA, Bonilla TD, Yowell CA, Fujioka H, Dame JB (2007) Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function.
Of note, it has recently also been shown that the activation of food vacuole plasmepsins is primarily mediated by falcipains, offering further evidence of a primary role for falcipains in mediating the hydrolysis of hemoglobin by erythrocytic
Bonilla JA, Moura PA, Bonilla TD, Yowell CA, Fidock DA, et al. (2007) Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum.
Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, et al. (2008) Plasmodium food vacuole plasmepsins are activated by falcipains.
However, it remains possible that they also perform other key functions, including the processing of plasmepsins (as discussed above) and possibly other food vacuole proteases
Banerjee R, Liu J, Beatty W, Pelosof L, Klemba M, et al. (2002) Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine.