from The Century Dictionary.

  • noun A name given by Dulong to ophioxylin, through an error in identifying the plant from which he obtained the compound.

from the GNU version of the Collaborative International Dictionary of English.

  • noun (Chem.) A crystalline substance said to be found in the root of a certain plant of the Leadwort (Plumbago) family.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun organic chemistry The toxin 5-hydroxy-2-methyl-1,4-naphthoquinone.


from Wiktionary, Creative Commons Attribution/Share-Alike License

plumbago +‎ -in


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  • It includes a non-nitrogenous principle, plumbagin, existing in the form of orange-yellow needles, bitter, acrid, volatile, neutral, slightly soluble in cold water, more soluble in ether, alcohol and hot water.

    The Medicinal Plants of the Philippines

  • Studies have shown that plumbagin, when administered orally at a dose of 4 mg / kg body weight, caused tumour regression in rats with 3-methyl-4­dimethyl aminoazobenzene (3MeDAB) - induced hepatoma.

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  • Hypolipidaemic activity: When administered to hyperlipidaemic rabbits, plumbagin reduced serum cholesterol and

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  • Eye drops containing 50 llg / ml of plumbagin demonstrated significant antibacterial, antiviral and antichlamydial effects in eye diseases with few side effects.

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  • Immunomodulatory activity: The effect of plumbagin was studied on peritoneal macro phages of BALB / c mice, evaluated by bactericidal activity, hydrogen peroxide production and superoxide anion release.

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  • Furthermore, plumbagin treatment prevented the accumulation of cholesterol and triglycerides in the liver and aorta and caused regression of atheromatous plaques of the thoracic and abdominal aorta.

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  • However, it was completely prevented when plumbagin was added to the medium and this was attributed to prevention of antibiotic resistance.

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  • Antioxidant activity: At a concentration of 1 mM, plumbagin prevented peroxidation in liver and heart homogenates.

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  • The LDso of plumbagin is approximately 10 mg / kg body weight (oral and IP) in mice and a 50\% alcoholic extract of the root or whole plant has an LD50 of 500 mg / kg body weight when given IP. 26 In view of the documented abortifacient activity, it should be avoided at all stages of pregnancy.

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  • The animals treated with plumbagin excreted more faecal cholesterol and phospholipids.

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