Definitions
from The Century Dictionary.
- noun A bitter crystalline substance, C15H14O6 + 2H2O, found in the root of the May-apple, Podophyllum peltatum. It melts at 117° C. or, when anhydrous, at 157° C.: used as a purgative.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
toxin obtained from therhizomes of some South American plants that is the base of theanticancer drugetoposide .
Etymologies
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Examples
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Part 1: Isolation and characterization of deoxy-podophyllotoxin.
Chapter 5 1953
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Previous research demonstrated that American mayapple leaves contain podophyllotoxin, making way for the development of American mayapple as a high-value crop for American growers.
THE MEDICAL NEWS 2009
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Podophyllyum emodi, produces podophyllotoxin, a compound used in manufacturing etoposide, the active ingredient in a drug used for treating lung and testicular cancer.
THE MEDICAL NEWS 2009
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"We hypothesized that there might be great variation with respect to podophyllotoxin content within American mayapple across the eastern United States."
THE MEDICAL NEWS 2009
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Currently, podophyllotoxin is produced commercially using the roots and rhizomes of Indian mayapple, an endangered species harvested from the wild in India, Pakistan, Nepal, and China.
THE MEDICAL NEWS 2009
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Currently, podophyllotoxin is produced commercially using the roots and rhizomes of Indian mayapple, an endangered species harvested from the wild in India, Pakistan, Nepal, and China.
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In agreement with our results, Stoilov et al. also found that compounds identified via HTS with a minigene reporter construct in HEK 293 cells were capable of specifically enhancing inclusion of exon 10 in endogenous transcripts of The most potent small molecules identified by our DMD exon skipping screen were podophyllotoxin tubulin modulators, and HDAC inhibitors TSA and scriptaid.
PLoS ONE Alerts: New Articles Debra A. O'Leary et al. 2009
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According to Zheljazkov; "The objective of this study was to estimate podophyllotoxin concentration in American mayapple across its natural habitats in the eastern United States and to identify high podophyllotoxin types that could be used for further selection and cultivar development."
THE MEDICAL NEWS 2009
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The researchers studied the effect of location, plant nutrient concentration, and phytoavailable nutrients in soil on podophyllotoxin concentration in American mayapple across its natural habitats in the eastern United States.
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This groundbreaking study confirmed that mayapple colonies in the eastern part of the United States can be used for the development of high podophyllotoxin cultivars, which could subsequently provide the base for commercial production of podophyllotoxin in the United States.
THE MEDICAL NEWS 2009
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