Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry A protein (or one of a larger group) whose function is to modify gene expression via changes to chromatin

Etymologies

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Examples

  • Through a series of experiments, the team worked backward from this observation to show that a group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and,

    dailyindia.com News Feed 2010

  • A group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and,

    innovations-report 2010

  • Through a series of experiments, the team worked backward from this observation to show that a group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and,

    dailyindia.com News Feed 2010

  • A group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and,

    innovations-report 2010

  • The mechanism by which 'polycomb' proteins critical for embyronic stem cell function and fate are targeted to DNA has been identified by UCL scientists.

    PhysOrg.com - latest science and technology news stories 2010

  • Discovering that polycomb also binds to these RNAs shows how polycomb might be recruited to genes, which are then repressed to maintain the identities of different cell types.

    PhysOrg.com - latest science and technology news stories 2010

  • However, although polycomb proteins repress genes, they are actually in

    PhysOrg.com - latest science and technology news stories 2010

  • PRC2 (polycomb repressive complex-2) is present in all multicellular organisms and has been shown to be important in stem cell differentiation and early embryonic development.

    PhysOrg.com - latest science and technology news stories 2010

  • Furthermore, profiling data of genes coding for chromatin regulators of homeobox genes, including components of polycomb repressor complex 2 (PRC2), indicated lacking expression of EZH2 in LOUCY and exclusive expression of

    BioMed Central - Latest articles Stefan Nagel 2010

  • Moreover, targets of the polycomb repressor complex in breast cancer and embryonic stem cells were more methylated in luminal B tumours than in other tumours.

    BioMed Central - Latest articles Karolina Holm 2010

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