Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun The use of several
drugs to treat a singlecondition ;polypharmacy .
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Savella-treated patients are on polytherapy for fibromyalgia, which is similar to the current experience for Cymbalta and Lyrica.
Forest Laboratories Q3 2011 Earnings Call Transcript - Seeking Alpha 2011
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This finding differs from prior studies that suggest poorer HRQOL is associated with polytherapy and improved HRQOL after conversion from multi-AED treatment to monotherapy.
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The medical community has extensively debated the value of monotherapy versus polytherapy, not only for relative efficacy in reducing frequency of seizures, but also for impact on health-related quality of life (HRQOL).
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"There was no major difference in frequency of the recorded adverse effects between patients on monotherapy and patients on polytherapy," confirmed Emilio Perucca, M.D., of the University of Pavia and lead author of the SOPHIE (Study of Outcome of PHarmacoresistance In Epilepsy) study.
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This finding differs from prior studies that suggest poorer HRQOL is associated with polytherapy and improved HRQOL after conversion from multi-AED treatment to monotherapy.
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"There was no major difference in frequency of the recorded adverse effects between patients on monotherapy and patients on polytherapy," confirmed Emilio Perucca, M.D., of the University of Pavia and lead author of the SOPHIE (Study of Outcome of PHarmacoresistance In Epilepsy) study.
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"In the second odds ratio of 1.68," she said, "showing a 68 percent increased risk, now we are comparing women who took Paxil either alone or in combination with another SSRI, compared to the other SSRI group, either alone or in combination with other SSRIs, mono - or polytherapy."
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Results also showed that polytherapy patients had higher drug loads than monotherapy patients.
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In the 627 subjects (77. 7%) subjects on polytherapy, levetiracetam was the most commonly co-prescribed drug.
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However, only about one-half of patients become seizure-free with the first prescribed AED; an additional 20% of patients may find complete relief from seizures through a polytherapy AED regimen.
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