polyubiquitination

As distinct from reversible protein modifications such as phosphorylation (Nobel Prize in Physiology or Medicine 1992), regulation through polyubiquitination is often irreversible since the target protein is destroyed.

The Nobel Prize in Chemistry 2004 - Information for the Public 2004

The idea was that the same defect in monoubiquitination of the histone may affect also protein degradation which involves polyubiquitination, though it was clear that the single modification of the histone molecule by ubiquitin does not lead to its targeting to proteolysis.

Aaron Ciechanover - Autobiography 2005

We now know that this polyubiquitination of substrate proteins is the triggering signal that leads to degradation of the protein in the proteasome.

The Nobel Prize in Chemistry 2004 - Information for the Public 2004

In the second work it was further shown that many APF-1 molecules could be bound to the same target protein; the latter phenomenon was termed polyubiquitination.

The Nobel Prize in Chemistry 2004 - Information for the Public 2004

This mechanism for adding a chain of ubiquitins to a protein is called K63 polyubiquitination, and is distinct from the way in which a cell builds the ubiquitin chain that flags unwanted proteins for destruction.

HHMI News 2010

Since previous research had suggested that RIG-I might also need K63 polyubiquitination to become active, Chen's team added in ubiquitin and the enzymes that could construct the K63 chains.

HHMI News 2010

In contrast, the ARF gene product prevents MDM2-mediated polyubiquitination of p53, thereby inhibiting its proteasomal degradation.

PLoS ONE Alerts: New Articles 2009

We show that is also subject to polyubiquitination.

Journal of Biological Chemistry current issue 2009

Western blotting experiments in addition confirmed that coadministration of salubrinal did not modulate the extend of polyubiquitination (

PLoS ONE Alerts: New Articles 2009