Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
drug used to treatequine protozoal myeloencephalitis inhorses .
Etymologies
Sorry, no etymologies found.
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Examples
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"Based on reported side effects, ponazuril and diclazuril seem to have the fewest reported adverse effects."
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She explained that sulfadiazine/pyrimethamine combination (Rebalance), ponazuril (Marquis), and nitazoxanide (Navigator) medications are the approved treatments that have been commercially available, while diclazuril is approved for EPM treatment, but is not yet marketed.
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Recent research has investigated one more option, Johnson reported -- that of toltrazuril sulfone or ponazuril given at a loading dose along with dimethyl sulfoxide (DMSO) to improve uptake of the medications.
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Diclazuril's mode of action is unknown, but might be similar to that of the related medication ponazuril; it is also given for 28 days.
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For example, shipping stress is a known risk factor for development of EPM, and pretreatment with ponazuril prior to -- and during -- periods of similar stress might decrease the risk of disease.
TheHorse.com News 2009
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Pretreatment of horses with ponazuril has been shown to decrease the risk of infection with
TheHorse.com News 2009
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Diclazuril, a very similar compound to ponazuril, has received FDA approval, but it has not been released by the company as of this writing.
TheHorse.com News 2009
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