Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun genetics (
medicine ) An individual who presents with agenetic disorder or other specific characteristic, when this leads to the investigation of the individual'sfamily
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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We selected husbands as proband for consistency with sibling analyses (oldest sibling was defined as proband) since generally husbands are older than their wives.
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A proband (the first affected family member who seeks medical attention for a genetic disorder) diagnosed with a sarcoma at less than 45 years of age
Li-Fraumeni Syndrome 2009
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Family histories were collected from 114 homosexual male probands who were asked to rate their fathers, sons, brothers, uncles, and male cousins as either definitely homosexual (Kinsey 5 or 6, acknowledged to the proband or another family member) or not definitely known to be homosexual (heterosexual, bisexual, or unclear).
The Science of Desire Dean Hamer 1994
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Family histories were collected from 114 homosexual male probands who were asked to rate their fathers, sons, brothers, uncles, and male cousins as either definitely homosexual (Kinsey 5 or 6, acknowledged to the proband or another family member) or not definitely known to be homosexual (heterosexual, bisexual, or unclear).
The Science of Desire Dean Hamer 1994
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We sequenced the whole genome of the proband, identified all potential functional variants in genes likely to be related to the disease, and genotyped these variants in the affected family members.
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We sequenced the whole genome of the proband, identified all potential functional variants in genes likely to be related to the disease, and genotyped these variants in the affected family members.
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We sequenced the whole genome of the proband, identified all potential functional variants in genes likely to be related to the disease, and genotyped these variants in the affected family members.
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We sequenced the whole genome of the proband, identified all potential functional variants in genes likely to be related to the disease, and genotyped these variants in the affected family members.
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Results We identified and validated compound, heterozygous, causative alleles in SH3TC2 (the SH3 domain and tetratricopeptide repeats 2 gene), involving two mutations, in the proband and in family members affected by Charcot-Marie-Tooth disease.
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Results We identified and validated compound, heterozygous, causative alleles in SH3TC2 (the SH3 domain and tetratricopeptide repeats 2 gene), involving two mutations, in the proband and in family members affected by Charcot-Marie-Tooth disease.
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