Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun genetics (medicine) An individual who presents with a genetic disorder or other specific characteristic, when this leads to the investigation of the individual's family

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

[German Proband, person being tested, test subject, from Latin probandus, gerundive of probāre, to test; see prove.]

Support

Help support Wordnik (and make this page ad-free) by adopting the word proband.

Examples

  • We selected husbands as proband for consistency with sibling analyses (oldest sibling was defined as proband) since generally husbands are older than their wives.

    PLoS ONE Alerts: New Articles 2009

  • A proband (the first affected family member who seeks medical attention for a genetic disorder) diagnosed with a sarcoma at less than 45 years of age

    Li-Fraumeni Syndrome 2009

  • Family histories were collected from 114 homosexual male probands who were asked to rate their fathers, sons, brothers, uncles, and male cousins as either definitely homosexual (Kinsey 5 or 6, acknowledged to the proband or another family member) or not definitely known to be homosexual (heterosexual, bisexual, or unclear).

    The Science of Desire Dean Hamer 1994

  • Family histories were collected from 114 homosexual male probands who were asked to rate their fathers, sons, brothers, uncles, and male cousins as either definitely homosexual (Kinsey 5 or 6, acknowledged to the proband or another family member) or not definitely known to be homosexual (heterosexual, bisexual, or unclear).

    The Science of Desire Dean Hamer 1994

  • We sequenced the whole genome of the proband, identified all potential functional variants in genes likely to be related to the disease, and genotyped these variants in the affected family members.

    Medlogs - Recent stories 2010

  • We sequenced the whole genome of the proband, identified all potential functional variants in genes likely to be related to the disease, and genotyped these variants in the affected family members.

    Medlogs - Recent stories 2010

  • We sequenced the whole genome of the proband, identified all potential functional variants in genes likely to be related to the disease, and genotyped these variants in the affected family members.

    Medlogs - Recent stories 2010

  • We sequenced the whole genome of the proband, identified all potential functional variants in genes likely to be related to the disease, and genotyped these variants in the affected family members.

    Medlogs - Recent stories 2010

  • Results We identified and validated compound, heterozygous, causative alleles in SH3TC2 (the SH3 domain and tetratricopeptide repeats 2 gene), involving two mutations, in the proband and in family members affected by Charcot-Marie-Tooth disease.

    Medlogs - Recent stories 2010

  • Results We identified and validated compound, heterozygous, causative alleles in SH3TC2 (the SH3 domain and tetratricopeptide repeats 2 gene), involving two mutations, in the proband and in family members affected by Charcot-Marie-Tooth disease.

    Medlogs - Recent stories 2010

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.